PATIENT WITH
LIVER DISORDERS:
EXPLORATION
TOOLS AND TREATMENT
Donea LORENZA1, Camelia Salloum
COJOCARIU2, Ana-Maria SINGEAP2, Irina
GIRLEANU2, Anca
TRIFAN2
1 Emergency Pediatric Clinical Hospital Sf nta Maria
Iași, Pediatric Gastroenterology Clinic
2 Gastroenterology
Medical Clinic II, Medicine Faculty, UMF Grigore T.Popa Iasi
Abstract. The evaluation of the liver structure can be done through invasive and
non-invasive imaging methods. Noninvasive methods include abdominal ultrasound,
transient hepatic elastography (Fibroscan). biomarkers such as hyaluronic acid
(HA), alpha-2 macroglobulin, laminin, fibronectin, Fibroindex or panels such as
Fibrotest-actiTest. Liver biopsy, the most invasive method of assessing the
structure of the liver and the lesions present, is still indicated in certain
reserved cases, when the diagnosis remains uncertain despite all the
investigations. Antiviral therapy in Romania for hepatitis B virus includes the
administration of pegylated interferon alfa 2a and various
nucleoside/nucleotide analogs (ANN): adefovir, entecavir, tenofovir,
lamivudine. IFNα is the most effective antiviral treatment in children,
regarding the seroconversion of Hbe Ag to anti Hbe Ac and the disappearance of
Hbs Ag. Sustained response is defined as maintaining the response to treatment
for at least 6 months after its discontinuation.
Keywords: liver,
investigation, treatment, non-invasive, invasive
DOI https://doi.org/10.56082/annalsarscibio.2022.2.112
